VITAMIN D SUPPLEMENTATION DECREASES THE BODY FAT STORES AND PLASMA OXIDATIVE STRESS OF OBESE RATS

The study aimed to verify the effects of vitamin D3 (cholecalciferol) supplementation on thebody fat composition and plasmatic oxidative stress obese rats. 21 days old maleWistar rats were acclimatized in sectorial animal breed until they 30 old(CEUA nº 5866200720). Then obesity induction was initiated using cafeteria diet(Western Diet; WD). animals divided into 2 groups: CTL, fed a normal diet;WD, WD. After 90 old, subdivided two other CTL-VD WD-VD, which received during 40 (5.600 UI/week by gavage). At130 blood collected plasma separated for assays.After, body deposits collected, weighed. adiposity index WDrats higher than CTL WD-VD animals. epididymal, retroperitoneal andmesenteric WD respectively 30%, 46% 50% whencompared Body weight gain abdominal also decreased inanimals supplemented with D3. Regarding parameters theplasma, levels carbonyl protein groups lower, thiol totalantioxidant capacity (TAC) when compared WD-VDgroups. In conclusion, treatment VD3 able reduce both stores ofoxidative markers diet-induced obesity.